Activation of the nonnociceptive nerve fibers results in the close of the gate. This means that only signals transmitted by nonnociceptive nerves will reach the brain. The signals transmitted by A & C-Delta fibers are thwarted, therefor pain will not be perceived by the brain.

Nonnociceptive nerve fibers can be activated by different means: acupuncture, acupressure, cold packs, electronic devices and menthol.

The recent scientific research has proven that menthol stimulates the TRPM8 cold receptors at the level of the skin.

Perozin® releases the encapsulated Menthol gradually on to the surface of the skin, stimulating the nonnociceptive nerves for a prolonged period of time.

According to the gate control theory, pain perception is a balance between information traveling into the spinal cord through two types of nonciceptive nerves:
i. Large nerve fibers (C-Delta nerve fibers), transmit chronic pain.
ii. Small nerve fibers( A-Delta nerve fibers), transmit intense pain.
A third type “nonnociceptive” (A-beta nerve fibers) are Inhibitory Neurons, they do not transmit pain.


Apply a small portion of Perozin and rub it 1 to 3 times a day onto the affected area. The best results are obtained by rubbing Perozin before and after a hot bath.
Perozin is for external use only. Avoid contact with eyes and keep out of the reach of children. Wash hands after each use.

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